Connect with the CTML community! This week’s seminar on Wednesday, January 28th, will feature CTML GSR Kaitlyn Lee presenting her talk, "Improving Precision through Covariate Adjustment in RCTs with Binary Outcomes." The seminar will take place at 12:00 PM in Berkeley Way West, 5th Floor, Room 5401. Please note that this week’s session will be open exclusively to the CTML Community and the BPH Biostatistics community.
Covariate adjustment is a general method for improving precision when estimating treatment effects in randomized trials and is recommended by the FDA in its recent guidance when baseline variables are prognostic for the primary outcome. In this talk, we review the principles underlying covariate adjustment, with a focus on standardization, a method highlighted in the guidance for estimating the marginal treatment effect. We concentrate on settings with binary outcomes, describing practical implementation of the estimator and discussing open questions related to variance estimation and finite-sample performance.