Estimating the effect of realistic improvements of metformin adherence on COVID-19 mortality using targeted machine learning

Abstract: 

Type 2 diabetes elevates the risk of severe outcomes in COVID-19 patients, with multiple studies reporting higher case fatality rates. Metformin is a widely used medication for glycemic management. We hypothesize that improved adherence to metformin may lower COVID-19 post-infection mortality risk in this group. Utilizing data from the Mexican Social Security Institute (IMSS), we investigate the relationship between metformin adherence and mortality following COVID-19 infection in patients with chronic metformin prescriptions.

Author: 
Juan Pablo Gutiérrez
Ganesh Pimpale
Arturo Juárez-Flores
Rakesh Ghosh
Iván de Jesús Ascencio-Montiel
Stefano M Bertozzi
Publication date: 
June 1, 2024
Publication type: 
Journal Article