Review 1: "Leveraging Pre-Vaccination Antibody Titers across Multiple Influenza H3N2 Variants to Forecast the Post-Vaccination Response"

The phrase “predictive understanding” doesn’t quite make sense, as prediction often foregoes understanding in the name of predictive accuracy. Perhaps a phrase such as “ability to predict” may be more clear.

“20k data points” is a bit vague. Does this refer to all covariate information, outcomes, etc.?

Additional context could be provided for the phrase “These datasets formed a blinded prediction challenge, where the computational team only received the pre-vaccination data yet predicted the post-vaccination responses with 2.2-fold error, comparable to the 2-fold intrinsic error of the experimental assay.” While this will likely be clear to vaccination experts, it would be useful to provide context on this comparison, given the broad readership of RR\ID. The following section provides a great overview of this context, but it would be helpful to provide a short allusion in the abstract, or remove this comparison.